Rac1, a member 112 of the Rho family of small GTPases, has been shown to promote formation of lamellipodia at the leading edge of motile cells and affect cell migration.We previously demonstrated that calmodulin can bind to a region in the C-terminal of Rac1 and that this interaction is important in the activation of platelet Rac1.Now, we have anal
Jejunal villus absorption and paracellular tight junction permeability are major routes for early intestinal uptake of food-grade TiO2 particles: an in vivo and ex vivo study in mice
Abstract Background Food-grade TiO2 (E171 in the EU) is widely used as a coloring agent in foodstuffs, including sweets.Chronic dietary exposure raises concerns for human health due to proinflammatory properties and the ability to induce and promote preneoplastic lesions in the rodent gut.Characterization of intestinal TiO2 uptake is essential for
Self-induced consensus of Reddit users to characterise the GameStop short squeeze
Abstract The short squeeze of GameStop (GME) shares in mid-January 2021 has been primarily orchestrated by retail investors of the Reddit r/wallstreetbets community.As such, it represents a paramount example of collective coordination action on social media, resulting in large-scale consensus formation and significant market impact.In this work we
THE CASE OF THE GIANT-CELL ARTERITIS MANIFESTED AS DORSOLATERAL MEDULLARY INFARCTION
Makeup Sponge The case of a giant-cell arteritis is presented.First clinical signs of the disease were fewer and development of infarction in the basin of the left vertebral artery.Magnetic resonance angiography showed its prolonged diminution.Laboratory results were remarkable for the high rate of erythrocyte sedimentation and the increase of C-re
Endovascular catheter arterial embolization effectively treats secondary hypertension and increased plasma B-type natriuretic peptide level accompanied by idiopathic renal arteriovenous fistula
A 65-year-old woman with a history of hypertension and atrial fibrillation was referred to our hospital Outdoor Barstool following detection of microscopic hematuria.Physical examination showed continuous vascular murmur with the maximum point on the right side of the umbilicus.Contrast-enhanced computed tomography showed a right renal aneurysmal-t